1038 Improving Adherence to Antibiotic Guidelines for the Treatment of Acute Cholecystitis: A Completed Audit Cycle

Abstract Aim Acute cholecystitis (AC) accounts for up to one third of emergency surgical admissions. The initial management AC includes fluid resuscitation and appropriate antibiotic therapy. aim this study is audit compliance with local microbiology guidelines the treatment develop interventions that improve rates. Method All patients admitted from September December 2020 radiologically confirmed were included in an prospective (n=39 patients). Antibiotic prescriptions, patient demographics, presence fever (>38°C), inflammatory markers liver function tests recorded. results disseminated, educational material produced, “champions” appointed adherence guidelines. A re-audit was conducted May June 2021 establish effectiveness (n=49 Compliance rates before after compared using a Chi-squared test. Binomial logistic regression carried out whether any demographic or clinical parameters independent predictors prescribing behaviour. Results significantly improved following (12.8% vs 57.1%; p<0.001). Age, gender, temperature, markers, comparable both groups not found be non-compliant prescription. Conclusions Adherence can appointment individuals responsible ensuring correct Interestingly, signs sepsis did influence behaviour, suggesting divergence may due ingrained dogma.